A Study on Neer Peenisam

The research on “Neer Peenisam” is chosen with an intention to give solace to the patients who are suffering from this disease without any noxious effects. Various literatures having relevant reference to the disease “Neer Peenisam” were collected from both siddha system as well as is in modern system of medicine. The efficacy of the drugs “singathi chooranam” “chittrarathai kudineer” and “Dikkamalli thylam” were studied and observed during research. Fifty patients from both sexes of different age groups were selected and treated in the In & Out patient ward of Maruthuvam Department.NIS,Chennai-47. The patients were treated for 7 days depending upon the severity of the illness further follow up was done for 2 to 4 months for any recurrence. Available investigation in modern medicines were also considered for diagnosis and the progress of the patient was followed by the Performa was prepared accordingly. The clinical trial conducted with 50 patients. 33 Patients had good relief 12 Had moderate relief and 15 had mild relief. Research findings reveal about the disease and its impact in the body, statistics taken with the help of details in the case sheet, were dealt in detail in observation and results which gave clear knowledge about the disease. The potency of the drugs was studied by bio-chemical analysis, pharmacological studies. The drug singathi chooranam with chittrrarathai kudineer possesses Anti –histaminic, Analgesic and anti inflammatory actions. This analysis is ensuring the efficacy of the trial drugs which were proved clinically. CONCLUSION: When singathi chooranam with chittrarathai kudineer was administered to the patient along with Dikkamalli thylam for bath, it gives very good result. Research findings show that65 % of patients were completely cured and also proved clinically. The trial drugs were very effective to the patients.Cost of the drug is very cheap and free from side effects. So they are useful for long term purpose. The drugs along with yoga, pranayama and head massage as supportive therapy showed very good prognosis

A Study on Kalladaippu

The clinical trial was conducted in 30 patients of renal calculus with trial drug of kalladaippu thool in dose of 5gms twice a day with adjuvant of 50ml raddish juice. • Clinical diagnosis of kalladaippu was done in the basis of clinical features described in our text book. • Urine and haematological examination and ulrasonography were done before and after treatment of trial drug. • The various Siddha aspect examinations were carried out and recoded. • Kalladaippu in Siddha aspect was correlated with urinary calculus in modern aspect. • In biochemical study the trial drug had magnesium, potassium, citrates and tannin.Which are confirmed the clinical prognosis in renal calculus. • In pharmacological study showed that the trial drug had well diuretic action without adverse effect in dose of one gram per kg. • The medicine chooses for clinical treatment and management of kalladaippu by kalladaippu thool. • Observation of the trial drug in the clinical study was clinically effective. CONCLUSION: The clinical trial of kalladaippu thool was conducted in 30 patients for 8 weeks of period. • In the study 93.3 % of patients were clinically good improvement and 6.6% were moderate in improvement with trial drug. There were no clinically significant adverse reactions noted with trial drug. • In Siddha and modern aspect of urine investigation in all patients after treatment came down to normal. • Out of 30 patients, 19 patients were taken ultrasonography after treatment, among 19 patients, stone dissolved completely in 47.3% (9) and reduced size and number in 47.3% (9) of patients. Among 30 patients ureter stone removed in 13.3% (4) with short period of treatment. • In biochemical study the drug has potassium, magnesium, citrates and tannin were onfirmed. This helps in clinical prognosis of renal calculus. • The diuretic action of the trial drug had very good efficacy with anubanam in animal study and without toxic effect. • Expenditure of the trial drug is low in cost and easily preparable but highly efficacy in kalladaippu. • The clinical study was encouraging to do the deep study in large sample of kalladaippu patients with trial drug with proper diagnosis

A Study on Penn Maladu

The aim of the study is to evaluate the efficacy of the Siddha drugs ‘Maladu Neenga Thailam and Saaravalli Mathirai’ for the treatment of Penn Maladu. The drugs are prepared as per the literature. 20 patients are selected for the trial, based on inclusion and exclusion criteria. Before treatment, consent is obtained from the patients. With the help of routine blood and urine examination biochemical parameters, clinical markers and ultrasound, diagnosis is made. At least two markers should be positive. They are given trial drugs for 7 days and are instructed to come for next clinical visit after 7 days. Also they are asked to bring back the unconsumed drug during their next visit and return the same. The assessment form is noted in every clinical visit. At the end of treatment the clinical symptoms are reduced in majority of patients and ovulation occured in 75% patients. Of them 40% patients even conceived. There is failure of ovulation in 25% patients. After treatment no adverse-effect is noted. CONCLUSION: Clinical trial revealed that the trial drugs "Maladu Neenga Thailam and Saaravalli Mathirai" produce ovulation in 75% of cases and failure of ovulation in 25% of cases. There is no adverse effects observed during the course of treatment. It is concluded that these Drugs are effective in the treatment of Penn Maladu. Because of the encouraging results clinically, the study may be undertaken with the same drugs for a prolonged period of time in more number of cases and it may throw new lights for the treatment of Penn Maladu

CLINICAL EVALUATION OF A SIDDHA POLY HERBAL FORMULATION AZHINJIYATHIKASHAYAM IN MADHUMEGAM (TYPE - 2 DIABETES) PATIENTS

Azhinjiathikashayam is a herbo mineral Siddha poly herbal formulation said for the management of Madhumegam (Type-2 Diabetes mellitus) in ancient Siddha literature. The study drug was subjected to estimate the therapeutic efficacy in Madhumegam patients. A well designed study protocol was approve by Institutional Ethics Committee and the clinical study was conducted as an open clinical trial in OPD/IPD of Ayothidoss pandithar Hospital of National Institute of Siddha Chennai. Based on the inclusion criteria 40 Madhumegam patients (Type -2 Diabetes mellitus) were enrolled in this study. Informed consent was obtained from each patient before study initiation. 60ml of Azhinjiathikashayam was administered orally before food twice a day for a period of 90 days and advised to follow the prescribed dietary regimen. All the baseline data, Laboratory investigations were recorded in the prescribed Case Report Form of each patient. Blood sugar level in fasting and postprandial was done once in 30 days and HbA1c was done before treatment (0th day) and after treatment (90th day). The clinical assessment was recorded once in 10 days. Paired t test was used to test the significance of treatment using before and after treatment data on HbA1c, Clinical symptoms, Blood sugar fasting and postprandial. The level of significance probability 0.05 was used to test the treatment difference and the values are statistically significant. In this study there is statistically significant difference between before and after treatment on average HbA1c, average blood sugar of fasting and average clinical feature score (p < 0.0001)

PREVALENCE OF PAANDU (ANAEMIA) AMONGST PATIENTS REPORTING AT OUTPATIENT DEPARTMENT OF NATIONAL INSTITUTE OF SIDDHA

Anaemia is the most common nutritional problem in the world .In the outpatient department of National institute of Siddha the significant numbers of anaemia cases are reporting for treatment. As the part of partial completion of 1st year MD degree the investigator select the minor project to determine the data about prevalence of Paandu (Anaemia) in NIS OPD patients. This study includes 500 OPD patients. OPD patients in the age between 13-74 years were randomly selected daily (Systematic random sampling method). A pre-designed self-administrated questionnaire interview method is used for collecting data about the patients. Information on personal characteristics, socio economic status, diet, lab investigations, clinical profiles are obtained. The study results showed that the prevalence of anemia amongst patients reporting at NIS OPD were 45.6%. The mean haemoglobin concentration was 11.4g/dl in female and 12.8g/dl in male. Majority of female in reproductive age (15-49 years) had the highest prevalence of anemia. And the high proportion of microcytic hypochromic anaemia (22.2%) was founded in the selected samples which indicate that Iron deficiency was the main cause of anaemia. Effect of socio economic status on anemic patients reported in NIS also calculated according to ‘Modified Kuppusamy socio economic scale’ which results that patients belongs to the upper lower status (12.2%) are more prone to anemia. Therefore the results of this study can be used to design target interventions aimed at reducing the prevalence of anemia in NIS OPD and to help conduct the interactive educational programs for improve disease awareness in female patients especially. And further studies are needed for clarify prevalence and etiology of anaemia in school going children (Below 13 years) at NIS OPD